| ACROSS
1. An antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain.
5. Experiencing or showing sorrow or unhappiness.
8. A period marked by distinctive character or reckoned from a fixed point or event.
11. Inspired by a feeling of fearful wonderment or reverence.
12. The corporate executive responsible for the operations of the firm.
13. A metric unit of volume or capacity equal to 10 liters.
14. Mentally or physically infirm with age.
15. (informal) Of the highest quality.
16. A nucleic acid consisting of large molecules shaped like a double helix.
17. Animal reproductive body consisting of an ovum or embryo together with nutritive and protective envelopes.
20. A river in north central Switzerland that runs northeast into the Rhine.
24. Made agreeably cold (especially by ice).
25. The capital of Croatia.
26. Related by common characteristics or ancestry.
28. A genus of Lamnidae.
31. A clique that seeks power usually through intrigue.
35. A particular geographical region of indefinite boundary (usually serving some special purpose or distinguished by its people or culture or geography).
37. (of champagne) Moderately dry.
40. A decree that prohibits something.
41. An enclosed space.
42. The bill in a restaurant.
44. A flat wing-shaped process or winglike part of an organism.
45. North American republic containing 50 states - 48 conterminous states in North America plus Alaska in northwest North America and the Hawaiian Islands in the Pacific Ocean.
46. Any wingless blood-sucking parasitic insect noted for ability to leap.
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DOWN
1. Having wisdom that comes with age and experience.
2. (informal) Valuable goods.
3. Popular music originating in the West Indies.
4. An agency of the United Nations affiliated with the World Bank.
5. Someone who works (or provides workers) during a strike.
6. A former agency (from 1946 to 1974) that was responsible for research into atomic energy and its peacetime uses in the United States.
7. Mature female of mammals of which the male is called `buck'.
8. Tropical starchy tuberous root.
9. Type genus of the Ranidae.
10. By bad luck.
18. A colorless and odorless inert gas.
19. Capital and largest city of Iraq.
21. A city in southern Turkey on the Seyhan River.
22. A type of submachine gun that is designed and manufactured in Israel.
23. Of or like a cecum.
27. A white soft metallic element that tarnishes readily.
29. Of or relating to or involving an area.
30. Joint capital (with Riyadh) of Saudi Arabia.
31. An agency of the United Nations affiliated with the World Bank.
32. A confusion of voices and other sounds.
33. Lower in esteem.
34. East Indian tart yellow berrylike fruit.
36. An amino acid that is found in the central nervous system.
38. A unit of heat equal to the amount of heat required to raise one pound of water one degree Fahrenheit at one atmosphere pressure.
39. An associate degree in applied science.
43. A gray tetravalent metallic element that resembles zirconium chemically and is found in zirconium minerals.
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